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Literature summary extracted from

  • Rawat, M.; Uppal, M.; Newton, G.; Steffek, M.; Fahey, R.C.; Av-Gay, Y.
    Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein (2004), J. Bacteriol., 186, 6050-6058.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.115 a mycothiol S-conjugate + H2O Mycolicibacterium smegmatis
-
 an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
3.5.1.115 a mycothiol S-conjugate + H2O Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
 an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.115 Mycolicibacterium smegmatis
-
-
-
3.5.1.115 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.115 a mycothiol S-conjugate + H2O
-
 Mycolicibacterium smegmatis an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
3.5.1.115 a mycothiol S-conjugate + H2O
-
 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
3.5.1.115 mycothiol-monobromobimane + H2O
-
 Mycolicibacterium smegmatis ? + 1D-myo-inosityl 2-amino-2-deoxy-glucopyranoside
-
 ?
3.5.1.115 mycothiol-monobromobimane + H2O
-
 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 ? + 1D-myo-inosityl 2-amino-2-deoxy-glucopyranoside
-
 ?
3.5.1.115 mycothiol-rifamycin S + H2O
-
 Mycolicibacterium smegmatis ?
-
 ?
3.5.1.115 mycothiol-rifamycin S + H2O
-
 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.115 MCA
-
 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
3.5.1.115 malfunction the Ami37 mutation in mca renders the mutant strain more susceptible to electrophilic toxins, such as N-ethylmalemide, iodoacetamide, and chlorodinitrobenzene, and to several oxidants, such as menadione and plumbagin. The mca mutant is also more susceptible to the antituberculous antibiotic streptomycin Mycolicibacterium smegmatis