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Literature summary extracted from

  • Bongard, R.D.; Krenz, G.S.; Gastonguay, A.J.; Williams, C.L.; Lindemer, B.J.; Merker, M.P.
    Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells (2011), Free Radic. Biol. Med., 50, 953-962.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 duroquinone stimulates NQO1 activity Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 NADH + H+ + duroquinone Bos taurus
-
 NAD+ + duroquinol
-
 ?
1.6.5.2 NADPH + H+ + duroquinone Bos taurus
-
 NADP+ + duroquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 endothelial cell pulmonary arterial, sulforaphane-treated Bos taurus
-
1.6.5.2 endothelium pulmonary Bos taurus
-
1.6.5.2 lung
-
 Bos taurus
-
1.6.5.2 additional information the enzyme is present in a wide range of tissue and cell types including the pulmonary endothelium and other lung cells Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 NADH + H+ + duroquinone
-
 Bos taurus NAD+ + duroquinol
-
 ?
1.6.5.2 NADPH + H+ + duroquinone
-
 Bos taurus NADP+ + duroquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Bos taurus
1.6.5.2 NQO1
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.6.5.2 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.6.5.2 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NADH
-
 Bos taurus
1.6.5.2 NADPH
-
 Bos taurus

Expression

EC Number Organism Comment Expression
1.6.5.2 Bos taurus NQO1 is inducible up