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Literature summary extracted from

  • Mitra, J.; Bhattacharyya, D.
    Irreversible inactivation of snake venom L-amino acid oxidase by covalent modification during catalysis of l-propargylglycine (2013), FEBS open bio, 3, 135-143.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.2 L-propargylglycine irreversible inhibition in a dose- and time-dependent manner Crotalus adamanteus
1.4.3.2 L-propargylglycine irreversible inhibition in a dose- and time-dependent manner Crotalus atrox

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.2 0.03601
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
1.4.3.2 0.03782
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
1.4.3.2 7.95
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
1.4.3.2 11.78
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.2 Crotalus adamanteus
-
-
-
1.4.3.2 Crotalus atrox
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.2 venom
-
 Crotalus adamanteus
-
1.4.3.2 venom
-
 Crotalus atrox
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.2 L-phenylalanine + H2O + O2
-
 Crotalus adamanteus phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.2 L-phenylalanine + H2O + O2
-
 Crotalus atrox phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.2 L-propargylglycine + O2 the substrate L-propargylglycine competes with the substrate L-Phe during inactivation of the enzyme Crotalus adamanteus 3-amino-5-methylene-5H-furan-2-one + H2O2
-
 ?
1.4.3.2 L-propargylglycine + O2 the substrate L-propargylglycine competes with the substrate L-Phe during inactivation of the enzyme Crotalus atrox 3-amino-5-methylene-5H-furan-2-one + H2O2
-
 ?
1.4.3.2 additional information glycine is not oxidized by the enzyme Crotalus adamanteus ?
-
 ?
1.4.3.2 additional information glycine is not oxidized by the enzyme Crotalus atrox ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.2 L-amino acid oxidase
-
 Crotalus adamanteus
1.4.3.2 L-amino acid oxidase
-
 Crotalus atrox
1.4.3.2 LAAO
-
 Crotalus adamanteus
1.4.3.2 LAAO
-
 Crotalus atrox

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.2 6.27
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
1.4.3.2 6.78
-
 L-phenylalanine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
1.4.3.2 7.75
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox
1.4.3.2 9.62
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.2 FAD
-
 Crotalus adamanteus
1.4.3.2 FAD
-
 Crotalus atrox

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.2 7.49
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus adamanteus
1.4.3.2 9.69
-
 L-propargylglycine in 20 mM Na-phosphate, pH 7.5, at 28°C Crotalus atrox