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Literature summary extracted from

  • Kurogi, K.; Sakakibara, Y.; Kamemoto, Y.; Takahashi, S.; Yasuda, S.; Liu, M.C.; Suiko, M.
    Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus (2010), FEBS J., 277, 3804-3811.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 expressed in NIH/3T3 cells and in Escherichia coli BL21 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.15 cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.15 38400
-
 x * 38400, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + cholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Mus musculus best substrate adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.15 3'-phosphoadenylylsulfate + pregnenolone Mus musculus
-
 adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
 ?
2.8.2.15 additional information Mus musculus the proline/serine-rich C-terminal tail is not required for the catalytic activity of SULT2B1b ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Mus musculus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.15 0.045
-
 full-length enzyme, using cholesterol as substrate, at pH 7.5 and 37°C Mus musculus
2.8.2.15 0.9599
-
 full-length enzyme, using pregnenolone as substrate, at pH 7.5 and 37°C Mus musculus
2.8.2.15 0.9993
-
 full-length enzyme, using dehydroepiandrosterone as substrate, at pH 7.5 and 37°C Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + cholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone best substrate Mus musculus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.15 3'-phosphoadenylylsulfate + pregnenolone
-
 Mus musculus adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
 ?
2.8.2.15 additional information the proline/serine-rich C-terminal tail is not required for the catalytic activity of SULT2B1b Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.15 ? x * 38400, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 sulfotransferase SULT2B1b
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.8.2.15 physiological function isoform SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus. Such an interaction allows the enzyme to move along microfilaments such as actin filaments, and catalyze the sulfation of hydroxysteroids at specific intracellular locations Mus musculus