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Literature summary extracted from

  • Kim, S.Y.; Kang, H.T.; Choi, H.R.; Park, S.C.
    Biliverdin reductase A in the prevention of cellular senescence against oxidative stress (2011), Exp. Mol. Med., 43, 15-23.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin reductase A
-
 Homo sapiens
1.3.1.24 BLVRA
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 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.24 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.24 8.5
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.24 physiological function BLVRA may be among the most effective physiological reactive oxygen species scavenging systems and may play an important role in regulating cellular senescence Homo sapiens
1.3.1.24 physiological function H2O2 markedly induces BLVRA activity in young human diploid fibroblasts, but not in senescent human diploid fibroblasts(HDF). Depletion of BLVRA reduces the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young human diploid fibroblasts, but not in senescent cells. Lentiviral RNAi transfected stable primary HDFs with reduced BLVRA expression show upregulation of the CDK inhibitor family members p16, p53, and p21, followed by cell cycle arrest in G0-G1 phase with high expression of senescence-associated beta-galactosidase Homo sapiens