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Literature summary extracted from

  • Urbschat, A.; Paulus, P.; von Quernheim, Q.F.; Brueck, P.; Badenhoop, K.; Zeuzem, S.; Ramos-Lopez, E.
    Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma (2013), Eur. J. Clin. Invest., 43, 1282-1290.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.24 medicine genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumours than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue. Gene expression of CYP2R1, CYP27B1 and CYP24A does not differ between pathological classifications Homo sapiens
1.14.15.18 medicine genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumors than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue. Gene expression of CYP2R1, CYP27B1 and CYP24A does not differ between pathological classifications Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.16 calcidiol + NADPH + H+ + O2 Homo sapiens
-
 secalciferol + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.24 Homo sapiens Q6VVX0
-
-
1.14.15.16 Homo sapiens
-
-
-
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.16 kidney
-
 Homo sapiens
-
1.14.15.16 renal cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 calcidiol + NADPH + H+ + O2
-
 Homo sapiens secalciferol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 CYP24A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.14.24 Homo sapiens genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumours than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue up
1.14.15.16 Homo sapiens the enzyme is upregulated in tumor cells compared with normal tissue up
1.14.15.18 Homo sapiens genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumors than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue up

General Information

EC Number General Information Comment Organism
1.14.15.16 physiological function upregulated gene expression of CYP24A1 leads to a misbalance of vitamin D metabolites in clear cell renal cell carcinomas and thus contributing to its pathogenesis Homo sapiens