EC Number | Cloned (Comment) | Organism |
---|---|---|
2.8.2.1 | expressed in Escherichia coli as fusion protein with maltose-binding protein | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.8.2.1 | 17alpha-ethinylestradiol | potent inhibitor, 17alpha-ethinylestradiol binds and inhibits isoform SULT1A1 activity toward 4-nitrophenol and 2-naphthol at low nanomolar concentrations, whereas the compound is not sulfated until significantly higher concentrations are reached | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.8.2.1 | 0.0024 | - |
17beta-estradiol | pH not specified in the publication, at 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.8.2.1 | 3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol | Homo sapiens | - |
? | - |
? | |
2.8.2.1 | 3'-phosphoadenylyl sulfate + 17beta-estradiol | Homo sapiens | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.8.2.1 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.8.2.1 | DEAE-Sepharose column chromatography and amylose affinity column chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.8.2.1 | liver | - |
Homo sapiens | - |
2.8.2.1 | MCF-7 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.8.2.1 | 3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol | - |
Homo sapiens | ? | - |
? | |
2.8.2.1 | 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Homo sapiens | ? | - |
? | |
2.8.2.1 | 3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.8.2.1 | sulfotransferase 1A1 | - |
Homo sapiens |
2.8.2.1 | SULT1A1 | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.8.2.1 | 0.0000089 | - |
17alpha-ethinylestradiol | for 4-nitrophenol sulfation, pH not specified in the publication, at 37°C | Homo sapiens | |
2.8.2.1 | 0.0000149 | - |
17alpha-ethinylestradiol | for 17beta-estradiol sulfation, pH not specified in the publication, at 37°C | Homo sapiens | |
2.8.2.1 | 0.000019 | - |
17alpha-ethinylestradiol | for 2-naphthol sulfation, pH not specified in the publication, at 37°C | Homo sapiens |