EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.5.1.20 | additional information | a C677T polymorphism is associated with an increased risk for the development of cardiovascular disease, Alzheimers disease, and depression in adults and of neural tube defects in the fetus | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.20 | 5,10-methylenetetrahydrofolate + NAD(P)H + H+ | Homo sapiens | - |
5-methyltetrahydrofolate + NAD(P)+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.20 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.20 | 5,10-methylenetetrahydrofolate + NAD(P)H + H+ | - |
Homo sapiens | 5-methyltetrahydrofolate + NAD(P)+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.1.20 | MTHFR | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.20 | NADH | - |
Homo sapiens | |
1.5.1.20 | NADPH | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.5.1.20 | malfunction | mutations in the enzyme lead to hyperhomocysteinemia. A C677T polymorphism is associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults and of neural tube defects in the fetus | Homo sapiens |
1.5.1.20 | metabolism | the enzyme plays a key role in folate metabolism and in the homeostasis of homocysteine | Homo sapiens |