EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.33 | (2-amino-2,3-dihydro-1H-benzimidazol-1-yl)(phenyl)methanone | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(2,5-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(2-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(2-fluorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(2-methylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(2-phenylethyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-4-methoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-4-phenyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-4-propoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-7-methoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-7-phenyl-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,4-dichlorobenzyl)-7-propoxy-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3,5-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(3-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(4-bromobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(4-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(4-methylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(4-tert-butylbenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(naphthalen-1-ylmethyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(naphthalen-2-ylmethyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(pyridin-2-yl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-(pyridin-3-yl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-benzyl-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-ethyl-2,3-dihydro-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1-[3-(trifluoromethyl)benzyl]-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 4-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 4-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 7-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei | |
1.5.1.33 | 7-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | - |
Trypanosoma brucei |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.33 | biopterin + 2 NADPH + 2 H+ | Trypanosoma brucei | - |
5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.33 | Trypanosoma brucei | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.33 | biopterin + 2 NADPH + 2 H+ | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.1.33 | pteridine reductase 1 | - |
Trypanosoma brucei |
1.5.1.33 | PTR1 | - |
Trypanosoma brucei |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.33 | NADPH | dependent on | Trypanosoma brucei |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.33 | 0.000007 | - |
1-(3,4-dichlorobenzyl)-7-phenyl-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.000047 | - |
1-(3,4-dichlorobenzyl)-7-propoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.000098 | - |
7-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.00031 | - |
1-(3,4-dichlorobenzyl)-4-propoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0004 | - |
1-(3,4-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.00046 | - |
1-(3,4-dichlorobenzyl)-4-methoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.00051 | - |
7-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.00065 | - |
1-(3,4-dichlorobenzyl)-7-methoxy-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0023 | - |
4-chloro-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0028 | - |
1-(naphthalen-2-ylmethyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0031 | - |
1-(4-bromobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0037 | - |
1-(2,5-dichlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0039 | - |
1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0042 | - |
1-(4-tert-butylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0054 | - |
1-(4-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0061 | - |
1-(naphthalen-1-ylmethyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0063 | - |
1-[3-(trifluoromethyl)benzyl]-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0075 | - |
1-(3-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.0088 | - |
1-(3,5-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.01 | - |
1-(2-chlorobenzyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.015 | - |
1-(2-methylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.015 | - |
1-(4-methylbenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.016 | - |
1-benzyl-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.016 | - |
4-(benzyloxy)-1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.021 | - |
1-(2-fluorobenzyl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.024 | - |
1-(2-phenylethyl)-2,3-dihydro-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.053 | - |
1-(pyridin-2-yl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.054 | - |
1-(pyridin-3-yl)-1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.06 | - |
(2-amino-2,3-dihydro-1H-benzimidazol-1-yl)(phenyl)methanone | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.06 | - |
1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.06 | - |
1-(3,4-dichlorobenzyl)-4-phenyl-1H-benzimidazol-2-amine | Ki above 0.06 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.2 | - |
1-ethyl-2,3-dihydro-1H-benzimidazol-2-amine | Ki above 0.2 mM, pH and temperature not specified in the publication | Trypanosoma brucei | |
1.5.1.33 | 0.228 | - |
1H-benzimidazol-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei |