Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lamberti, A.; Martucci, N.M.; Ruggiero, I.; Arcari, P.; Masullo, M.
    Interaction between the antibiotic tetracycline and the elongation factor 1alpha from the archaeon Sulfolobus solfataricus (2011), Chem. Biol. Drug Des., 78, 260-268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.3 tetracycline mixed inhibition. The inhibition level depends on the antibiotic concentration, even though a complete inhibition is not reached even in the presence of 0.120 mM antibiotic, a concentration corresponding to about 200fold molar excess over the elongation factor Saccharolobus solfataricus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.5.3 0.0025
-
 GTP pH 7.8, 60°C Saccharolobus solfataricus

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.3 Saccharolobus solfataricus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.3 GTP + H2O
-
 Saccharolobus solfataricus GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.3 elongation factor 1alpha
-
 Saccharolobus solfataricus
3.6.5.3 SsEF-1alpha
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.5.3 60
-
 assay at Saccharolobus solfataricus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.5.3 0.5
-
 GTP pH 7.8, 60°C Saccharolobus solfataricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.5.3 7.8
-
 assay at Saccharolobus solfataricus