EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.11.4 | medicine | LH2b is an interesting target to interfere with osteoarthritis-related persistent fibrosis | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.11.4 | gene PLOD2, encoding for splice variants LH2a and LH2b, quantitative expression analysis of LH2b | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.4 | L-lysine-[procollagen] + 2-oxoglutarate + O2 | Homo sapiens | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.4 | Homo sapiens | - |
gene PLOD2, encoding for splice variants LH2a and LH2b | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.4 | fibroblast | synovial osteoarthritic | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.4 | L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.4 | 2-oxoglutarate 5-dioxygenase 2 | - |
Homo sapiens |
1.14.11.4 | LH2b | - |
Homo sapiens |
1.14.11.4 | lysyl hydroxylase 2b | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.14.11.4 | Homo sapiens | in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.4 | metabolism | in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P | Homo sapiens |
1.14.11.4 | physiological function | lysyl hydroxylases are enzymes that catalyze the hydroxylation of lysine into hydroxylysine and, therefore, fulfill a crucial role in collagen modification and cross-linking. Lysyl hydroxylase 2b increases pyridinoline cross-links, making collagen less susceptible to enzymatic degradation | Homo sapiens |