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Literature summary extracted from

  • McGrath, A.P.; Caradoc-Davies, T.; Collyer, C.A.; Guss, J.M.
    Correlation of active site metal content in human diamine oxidase with trihydroxyphenylalanine quinone cofactor biogenesis (2010), Biochemistry, 49, 8316-8324.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.22 expressed in Drosophila melanogaster Schneider-2 cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.3.22 in complex with aminoguanidine, hanging drop vapor diffusion method, using 0.1M bis-Tris propane (pH 7.5), 20% (w/v) PEG3350, and 0.2 M sodium sulfate at 20°C Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 aminoguanidine potent, irreversible inhibitor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.22 Cu2+ the metal site is occupied approximately 75% by copper Homo sapiens
1.4.3.22 Zn2+ the metal site is occupied approximately 25% by zinc Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.22 histamine + H2O + O2 Homo sapiens
-
 (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Homo sapiens P19801
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.22
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 1,4-diaminobutane + H2O + O2
-
 Homo sapiens 4-aminobutanal + NH3 + H2O2
-
 ?
1.4.3.22 histamine + H2O + O2
-
 Homo sapiens (imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.22 homodimer x-ray crystallography Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.4.3.22 DAO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.22 2,4,5-trihydroxyphenylalanine quinone
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.22 0.000153
-
 in 100 mM potassium phosphate buffer (pH 7.2), at 37°C Homo sapiens aminoguanidine