Literature summary extracted from

Ogawa, M.; Nakamura, N.; Nakayama, Y.; Kurosaka, A.; Manya, H.; Kanagawa, M.; Endo, T.; Furukawa, K.; Okajima, T.
GTDC2 modifies O-mannosylated ?-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody (2013), Biochem. Biophys. Res. Commun., 440, 88-93.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.4.1.312	endoplasmic reticulum	-	Homo sapiens	5783	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.312	additional information	Homo sapiens	GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan in the endoplasmic reticulum	?	-	?
2.4.1.312	UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]	Homo sapiens	-	UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.312	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.312	additional information	GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan in the endoplasmic reticulum	Homo sapiens	?	-	?
2.4.1.312	UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]	-	Homo sapiens	UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.312	GTDC2	gene name, glycosyltransferase-like domain containing 2	Homo sapiens
2.4.1.312	O-mannose beta-1,4-N-acetylglucosaminyltransferase	-	Homo sapiens
2.4.1.312	POMGNT2	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.4.1.312	malfunction	mutations of GTDC2 are identified in Walker-Warburg syndrome	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)