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Literature summary extracted from

  • Lim, D.H.; Han, J.Y.; Kim, J.R.; Lee, Y.S.; Kim, H.Y.
    Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila (2012), Biochem. Biophys. Res. Commun., 419, 20-26.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 expressed in Drosophila melanogaster Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.12 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 dabsyl-L-methionine (R)-sulfoxide + dithiothreitol
-
 Homo sapiens dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine sulfoxide reductase B
-
 Homo sapiens
1.8.4.12 MsrB
-
 Homo sapiens
1.8.4.12 MsrB3A isoform Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.4.12 physiological function neuronal expression of isoform MsrB3A renders Drosophilaflies resistant to oxidative stress. These flies also show significantly enhanced cold (4°C) and heat (37°C) tolerance. Expression of isoform MsrB3A in the whole body and nervous system extends the lifespan of fruit flies at 29°C by 43-50% and 12-37%, respectively. Additionally, isoform MsrB3A overexpression significantly delays the age-related decline in locomotor activity and fecundity Homo sapiens