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Literature summary extracted from

  • Newton, G.L.; Fahey, R.C.
    Mycothiol biochemistry (2002), Arch. Microbiol., 178, 388-394.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.115 1,10-phenanthroline the enzyme is completely inhibited by low levels of 1,10-phenanthroline Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.115 a mycothiol S-conjugate + H2O Mycolicibacterium smegmatis the enzyme is extremely specific for the mycothiol portion of the mycothiol S-conjugate and relatively nonspecific with respect to the conjugate moiety an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
3.5.1.115 additional information Mycolicibacterium smegmatis the enzyme is nearly inactive with mycothiol, mycothiol disulfide, and Glc-NAc-Ins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.115 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.115 a mycothiol S-conjugate + H2O the enzyme is extremely specific for the mycothiol portion of the mycothiol S-conjugate and relatively nonspecific with respect to the conjugate moiety Mycolicibacterium smegmatis an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
3.5.1.115 additional information the enzyme is nearly inactive with mycothiol, mycothiol disulfide, and Glc-NAc-Ins Mycolicibacterium smegmatis ?
-
 ?
3.5.1.115 mycothiol-cerulenin + H2O
-
 Mycolicibacterium smegmatis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.115 MCA
-
 Mycolicibacterium smegmatis