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Literature summary extracted from

  • Gulcan, H.O.; Duffel, M.W.
    Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes (2011), Arch. Biochem. Biophys., 507, 232-240.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.15 dehydroepiandrosterone substrate inhibition Homo sapiens
2.8.2.15 additional information not inhibited by 3'-phosphoadenylylsulfate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.15 0.0008
-
 dehydroepiandrosterone in 0.25 M potassium phosphate buffer (pH 7.0), at 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.15 34000
-
 x * 34000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.15 DE52 anion exchange column chromatography and hydroxyapatite column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.15 ? x * 34000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 hydroxysteroid sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.15 0.008
-
 dehydroepiandrosterone in 0.25 M potassium phosphate buffer (pH 7.0), at 37°C Homo sapiens