EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | bezafibrate | i.e. 2-[4-[2-(4-chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid. In rats treated with 5, 10, 20 mg/kg bezafibrate mean enzyme actual activity is 1.9, 2.9, and 4.3fold higher than in the control group, respectively. Enzymatic total activity increases by 1.3 and 1.6fold in rats treated with 10 and 20 mg/kg bezafibrate | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.4 | BDK semi-quantitative real-time PCR expression analysis | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | Rattus norvegicus | - |
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | Rattus norvegicus | inactivation by phosphorylation of BCKDH | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
2.7.11.4 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | liver | - |
Rattus norvegicus | - |
2.7.11.4 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxoisovalerate + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
1.2.4.4 | 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
2.7.11.4 | ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] | inactivation by phosphorylation of BCKDH | Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.4.4 | BCKDH | - |
Rattus norvegicus |
1.2.4.4 | branched-chain alpha-keto acid dehydrogenase | - |
Rattus norvegicus |
1.2.4.4 | branched-chain alpha-ketoacid dehydrogenase complex | - |
Rattus norvegicus |
2.7.11.4 | branched-chain alpha-keto acid dehydrogenase kinase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | NAD+ | - |
Rattus norvegicus | |
2.7.11.4 | ATP | - |
Rattus norvegicus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.2.4.4 | Rattus norvegicus | mRNA expression is not upregulated by bezafibrate treatment | additional information |
2.7.11.4 | Rattus norvegicus | enzyme expression is reduced by 5% by bezafibrate | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.11.4 | metabolism | the enzyme is involved in the regulation of the branched-chain alpha-keto acid dehydrogenase complex by inactivating it through phopshorylation, complex regulation and effects of the drug benzofibrate, overview | Rattus norvegicus |