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Literature summary extracted from

  • Knapik-Czajka, M.
    Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate (2013), Toxicology, 306, 101-107.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 bezafibrate i.e. 2-[4-[2-(4-chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid. In rats treated with 5, 10, 20 mg/kg bezafibrate mean enzyme actual activity is 1.9, 2.9, and 4.3fold higher than in the control group, respectively. Enzymatic total activity increases by 1.3 and 1.6fold in rats treated with 10 and 20 mg/kg bezafibrate Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.4 BDK semi-quantitative real-time PCR expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.4.4 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine Rattus norvegicus
-
 [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Rattus norvegicus inactivation by phosphorylation of BCKDH ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Rattus norvegicus
-
-
-
2.7.11.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 liver
-
 Rattus norvegicus
-
2.7.11.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.4 2-oxoisovalerate + NAD+
-
 Rattus norvegicus ? + NADH
-
 ?
1.2.4.4 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] inactivation by phosphorylation of BCKDH Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.4 BCKDH
-
 Rattus norvegicus
1.2.4.4 branched-chain alpha-keto acid dehydrogenase
-
 Rattus norvegicus
1.2.4.4 branched-chain alpha-ketoacid dehydrogenase complex
-
 Rattus norvegicus
2.7.11.4 branched-chain alpha-keto acid dehydrogenase kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.4 NAD+
-
 Rattus norvegicus
2.7.11.4 ATP
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.2.4.4 Rattus norvegicus mRNA expression is not upregulated by bezafibrate treatment additional information
2.7.11.4 Rattus norvegicus enzyme expression is reduced by 5% by bezafibrate down

General Information

EC Number General Information Comment Organism
2.7.11.4 metabolism the enzyme is involved in the regulation of the branched-chain alpha-keto acid dehydrogenase complex by inactivating it through phopshorylation, complex regulation and effects of the drug benzofibrate, overview Rattus norvegicus