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Literature summary extracted from

  • Sun, L.; Wu, J.; Du, F.; Chen, X.; Chen, Z.J.
    Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway (2013), Science, 339, 786-791.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.86 DNA the cyclase activity is stimulated by DNA but not by RNA Homo sapiens
2.7.7.86 DNA the cyclase activity is stimulated by DNA but not by RNA Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.86 expressed in HEK293T cells Homo sapiens
2.7.7.86 expressed in HEK293T cells and expressed in Escherichia coli as a SUMO (small ubiquitin-related modifier protein) fusion protein Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.86 cytosol
-
 Homo sapiens 5829
-
2.7.7.86 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.86 ATP + GTP Homo sapiens cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
2.7.7.86 ATP + GTP Mus musculus cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.86 Homo sapiens Q8N884
-
-
2.7.7.86 Mus musculus Q8C6L5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.86
-
 Homo sapiens
2.7.7.86
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.86 ATP + GTP
-
 Homo sapiens 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
2.7.7.86 ATP + GTP
-
 Mus musculus 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
2.7.7.86 ATP + GTP cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines Homo sapiens 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?
2.7.7.86 ATP + GTP cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines Mus musculus 2 diphosphate + cyclic 3',5'-AMP-GMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.86 cGAMP synthase
-
 Homo sapiens
2.7.7.86 cGAMP synthase
-
 Mus musculus
2.7.7.86 cGAS
-
 Homo sapiens
2.7.7.86 cGAS
-
 Mus musculus