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Literature summary extracted from

  • Davis, M.I.; Sasaki, A.T.; Shen, M.; Emerling, B.M.; Thorne, N.; Michael, S.; Pragani, R.; Boxer, M.; Sumita, K.; Takeuchi, K.; Auld, D.S.; Li, Z.; Cantley, L.C.; Simeonov, A.
    A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation (2013), PLoS ONE, 8, e54127.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.149 (2E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
-
 Homo sapiens
2.7.1.149 (2E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile
-
 Homo sapiens
2.7.1.149 (3E)-5-amino-3-[(2Z)-1-cyano-2-(3H-indol-3-ylidene)ethylidene]-2,3-dihydro-1H-pyrazole-4-carbonitrile
-
 Homo sapiens
2.7.1.149 (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile
-
 Homo sapiens
2.7.1.149 additional information high-throughput inhibitor screening method, counterscreen assay and ATP competition assay, overview Homo sapiens
2.7.1.149 tyrphostin ATP-competitive inhibitors, i.e. tyrosine phosphorylation inhibitors, of isozyme PI5P4Kalpha Homo sapiens
2.7.1.149 tyrphostin 23
-
 Homo sapiens
2.7.1.149 tyrphostin 47
-
 Homo sapiens
2.7.1.149 tyrphostin AG 1478
-
 Homo sapiens
2.7.1.149 tyrphostin AG 490
-
 Homo sapiens
2.7.1.149 tyrphostin AG 494
-
 Homo sapiens
2.7.1.149 tyrphostin AG 537
-
 Homo sapiens
2.7.1.149 tyrphostin AG 555
-
 Homo sapiens
2.7.1.149 tyrphostin AG 698
-
 Homo sapiens
2.7.1.149 tyrphostin AG 808
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.149 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 phosphatidylinositol 5-phosphate 4-kinase
-
 Homo sapiens
2.7.1.149 PI5P 4-kinase
-
 Homo sapiens
2.7.1.149 PI5P4K
-
 Homo sapiens
2.7.1.149 PI5P4Kalpha
-
 Homo sapiens
2.7.1.149 type II kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.149 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.149 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.149 ATP
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.149 0.001
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin
2.7.1.149 0.002
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens (2E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile
2.7.1.149 0.005
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens (3Z)-2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile
2.7.1.149 0.013
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens (3E)-5-amino-3-[(2Z)-1-cyano-2-(3H-indol-3-ylidene)ethylidene]-2,3-dihydro-1H-pyrazole-4-carbonitrile
2.7.1.149 0.014
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens (2E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
2.7.1.149 0.018
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 808
2.7.1.149 0.02
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin 47
2.7.1.149 0.032
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 537
2.7.1.149 0.045
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin 23
2.7.1.149 0.05
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 698
2.7.1.149 0.055
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 555
2.7.1.149 0.089
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 494
2.7.1.149 0.089
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 490
2.7.1.149 0.1
-
 pH 7.4, 22°C, isozyme PI5P4Kalpha Homo sapiens tyrphostin AG 1478