Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hicks, A.N.; Lorenzetti, D.; Gilley, J.; Lu, B.; Andersson, K.E.; Miligan, C.; Overbeek, P.A.; Oppenheim, R.; Bishop, C.E.
    Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo (2012), PLoS ONE, 7, e47869.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain highest expression Mus musculus
-
2.7.7.1 embryo
-
 Mus musculus
-
2.7.7.1 lung low expression Mus musculus
-
2.7.7.1 additional information not expressed in heart, bladder, kidney and liver Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Mus musculus diphosphate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nicotinamide mononucleotide adenylyltransferase 2
-
 Mus musculus
2.7.7.1 NMNAT2 isoform Mus musculus

General Information

EC Number General Information Comment Organism
2.7.7.1 malfunction nicotinamide mononucleotide adenylyltransferase 2 (Nmat2) homozygous deletion mutants show an approximate 60% reduction of spinal motoneurons in the lumbar region and a more than 80% reduction in the sensory neurons of the dorsal root ganglion. In the absence of Nmnat2, major target organs and tissues (e.g., muscle) are not functionally innervated resulting in perinatal lethality Mus musculus
2.7.7.1 physiological function nicotinamide mononucleotide adenylyltransferase 2 regulates axon integrity in the mouse embryo Mus musculus