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Literature summary extracted from

  • Gondry, M.; Sauguet, L.; Belin, P.; Thai, R.; Amouroux, R.; Tellier, C.; Tuphile, K.; Jacquet, M.; Braud, S.; Courcon, M.; Masson, C.; Dubois, S.; Lautru, S.; Lecoq, A.; Hashimoto, S.; Genet, R.; Pernodet, J.L.
    Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes (2009), Nat. Chem. Biol., 5, 414-420.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.20 Streptomyces noursei Q8GED7
-
-
2.3.2.21 Mycobacterium tuberculosis
-
-
-
2.3.2.22 Bacillus subtilis
-
-
-
2.3.2.22 Streptomyces noursei Q8GED7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe
-
 Streptomyces noursei tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl) intermediate product of the biosynthetic pathway to albonoursin, cyclo(alpha,beta-dehydroPhe-alpha,beta-dehydroLeu) ?
2.3.2.20 additional information enzyme AlbC uses aminoacyl-tRNAs to synthesize various cyclodipeptides, including the reactions of cyclo(L-tyrosyl-L-tyrosyl) synthase, EC 2.3.2.21, and cyclo(L-leucyl-L-leucyl) synthase, EC 2.3.2.22 Streptomyces noursei ?
-
 ?
2.3.2.21 2 L-tyrosyl-tRNALeu
-
 Mycobacterium tuberculosis 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)
-
 ?
2.3.2.21 additional information cyclodipeptides synthesized by gene product Rv2275 always contain L-tyrosine Mycobacterium tuberculosis ?
-
 ?
2.3.2.22 2 L-leucyl-tRNALeu
-
 Bacillus subtilis 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2.3.2.22 2 L-leucyl-tRNALeu
-
 Streptomyces noursei 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2.3.2.22 additional information enzyme AlbC uses aminoacyl-tRNAs to synthesize various cyclodipeptides, including the reactions of cyclo(L-tyrosyl-L-tyrosyl) synthase, EC 2.3.2.21, and cyclo(L-phenylalanyl-L-leucyl) synthase, EC 2.3.2.20 Streptomyces noursei ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.21 cYY synthase
-
 Mycobacterium tuberculosis
2.3.2.21 Rv2275
-
 Mycobacterium tuberculosis
2.3.2.22 cLL synthase
-
 Bacillus subtilis
2.3.2.22 YvmC
-
 Bacillus subtilis