EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.1.74 | pharmacology | the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs | Mus musculus |
2.7.1.74 | pharmacology | the enzyme is a critical determinant of therapeutic activity for several nucleoside analogue prodrugs | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.74 | 0.00061 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
2.7.1.74 | 0.00076 | - |
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
2.7.1.74 | 0.00102 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens | |
2.7.1.74 | 0.00654 | - |
1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | pH 7.6, 37°C, recombinant enzyme | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.74 | cytosol | - |
Mus musculus | 5829 | - |
2.7.1.74 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | Mg2+ | required | Mus musculus | |
2.7.1.74 | Mg2+ | required | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + deoxyadenosine | Mus musculus | - |
ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxyadenosine | Homo sapiens | - |
ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxyadenosine | Mus musculus C57/BL6J | - |
ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | Mus musculus | - |
ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | Homo sapiens | - |
ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | Mus musculus C57/BL6J | - |
ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | Mus musculus | - |
ADP + dGMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | Homo sapiens | - |
ADP + dGMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | Mus musculus C57/BL6J | - |
ADP + dGMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.74 | Homo sapiens | - |
- |
- |
2.7.1.74 | Mus musculus | - |
- |
- |
2.7.1.74 | Mus musculus C57/BL6J | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.74 | additional information | dCK-negative L1210-10K tumors | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-bromocytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-chlorocytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | - |
Mus musculus | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate | - |
? | |
2.7.1.74 | ATP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine | - |
Homo sapiens | ADP + 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylcytosine monophosphate | - |
? | |
2.7.1.74 | ATP + clofarabine | - |
Mus musculus | ADP + clofarabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + clofarabine | - |
Homo sapiens | ADP + clofarabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + clofarabine | - |
Mus musculus C57/BL6J | ADP + clofarabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + deoxyadenosine | - |
Mus musculus | ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxyadenosine | - |
Homo sapiens | ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxyadenosine | - |
Mus musculus C57/BL6J | ADP + dAMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | - |
Mus musculus | ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxycytidine | - |
Mus musculus C57/BL6J | ADP + dCMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | - |
Mus musculus | ADP + dGMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | - |
Homo sapiens | ADP + dGMP | - |
? | |
2.7.1.74 | ATP + deoxyguanosine | - |
Mus musculus C57/BL6J | ADP + dGMP | - |
? | |
2.7.1.74 | additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Mus musculus | ? | - |
? | |
2.7.1.74 | additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Homo sapiens | ? | - |
? | |
2.7.1.74 | additional information | 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil is no substrate. But 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine can be converted to 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)uracil by cytidine deaminase | Mus musculus C57/BL6J | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.74 | dCK | - |
Mus musculus |
2.7.1.74 | dCK | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.74 | 37 | - |
assay at | Mus musculus |
2.7.1.74 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.74 | 7.6 | - |
assay at | Mus musculus |
2.7.1.74 | 7.6 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | ATP | - |
Mus musculus | |
2.7.1.74 | ATP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.74 | metabolism | deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway | Mus musculus |
2.7.1.74 | metabolism | deoxycytidine kinase is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway | Homo sapiens |
2.7.1.74 | additional information | biodistribution of cytosine derivative substrates in mouse healthy and malignant tissues, overview | Mus musculus |