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Literature summary extracted from

  • Sato, T.; Kudo, T.; Ikehara, Y.; Ogawa, H.; Hirano, T.; Kiyohara, K.; Hagiwara, K.; Togayachi, A.; Ema, M.; Takahashi, S.; Kimata, K.; Watanabe, H.; Narimatsu, H.
    Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism (2011), J. Biol. Chem., 286, 5803-5812.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.174 additional information generation of Csgalnact1-/- mice by using a targeting vector for Csgalnact1 gene disruption Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.174 UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?
2.4.1.174 UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus C57/BL6J
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.174 Mus musculus
-
-
-
2.4.1.174 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.174 brain quantitative analysis of Csgalnact1 and Csgalnact2 transcripts in brain of wild-type and Csgalnact1-/- mice by real-time PCR, overview Mus musculus
-
2.4.1.174 cartilage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.174 UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?
2.4.1.174 UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus C57/BL6J UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.174 chondroitin sulfate N-acetylgalactosaminyltransferase 1
-
 Mus musculus
2.4.1.174 CSGalNAcT-1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.1.174 malfunction the growth plate of Csgalnact1-/- mice contains shorter and slightly disorganized chondrocyte columns with a reduced volume of the extracellular matrix principally in the proliferative layer. Immunohistochemical analysis reveals that the level of both aggrecan and link protein 1 are decreased in Csgalnact1-/- cartilage with an increase in processed forms of aggrecan core protein, phenotype, overview Mus musculus
2.4.1.174 metabolism chondroitin sulfate biosynthetic pathway and relevant glycosyltransferases, overview Mus musculus
2.4.1.174 physiological function chondroitin sulfate N-acetylgalactosaminyltransferase 1, CSGalNAcT-1, participates in the chondroitin sulfate chain initiation and is necessary for normal endochondral ossification and aggrecan metabolism Mus musculus