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Literature summary extracted from

  • Lau, C.; Dolle, C.; Gossmann, T.; Agledal, L.; Niere, M.; Ziegler, M.
    Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases (2010), J. Biol. Chem., 285, 18868-18876.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.18 expression in HeLa S3 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.1 C164A/C165A the isoform NMAT2 mutant is consistently more strongly expressed than the wild type protein Homo sapiens
2.7.7.18 additional information generation of mutants lacking residues Glu107-Lys146. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoforms NMNAT1 are distributed throughout the cytoplasm Homo sapiens
2.7.7.18 additional information generation of mutants lacking residues Leu105-Ala125 of isoform NMNAT3. Overexpression of the construct results in a strong increase in overall enzymic activity compared with non-transfected cells Homo sapiens
2.7.7.18 additional information generation of mutants lacking residues Val109-Leu192. Overexpression of the constructs results in a strong increase in overall enzymic activity compared with non-transfected cells. The deletion mutants of isoform NMNAT2 are distributed throughout the cytoplasm Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 Golgi apparatus isoform NMAT2 Homo sapiens 5794
-
2.7.7.1 mitochondrion isoform NMAT3 Homo sapiens 5739
-
2.7.7.1 nucleus isoform NMAT1 Homo sapiens 5634
-
2.7.7.18 Golgi apparatus isoform NMNAT2 localizes to the cis-Golgi and endoplasmic reticulum-Golgi intermediate compartment. It is palmitoylated at two adjacent cysteine residues of its isoform-specific domain and thereby anchored at the cytoplasmic surface Homo sapiens 5794
-
2.7.7.18 mitochondrion isoform NMNAT3 is targeted to mitochondria by its N-terminus Homo sapiens 5739
-
2.7.7.18 additional information the three human isoforms NMNAT1-3 are localized to the nucleus, the Golgi complex, and mitochondria. Their genes contain unique exons that encode isoform-specific domains to mediate subcellular targeting and post-translational modifications. These domains are dispensable for catalytic activity Homo sapiens
-
-
2.7.7.18 nucleus sequence of isoform NMNAT1 contains a predicted nuclear localization signal Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.1 34000
-
 x * 34000, isoform NMAT2, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens Q96T66 isoform NMAT3
-
2.7.7.1 Homo sapiens Q9BZQ4 isoform NMAT2
-
2.7.7.1 Homo sapiens Q9HAN9 isoform NMAT1
-
2.7.7.18 Homo sapiens Q96T66 isoform NMNAT3
-
2.7.7.18 Homo sapiens Q9BZQ4 isoform NMNAT2
-
2.7.7.18 Homo sapiens Q9HAN9 isoform NMNAT1
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.1 palmitoylation isoform NMAT2 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 HeLa-S3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.1 ? x * 34000, isoform NMAT2, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Homo sapiens
2.7.7.1 NMNAT1 isoform Homo sapiens
2.7.7.1 NMNAT2 isoform Homo sapiens
2.7.7.1 NMNAT3 isoform Homo sapiens
2.7.7.18 NMNAT1
-
 Homo sapiens
2.7.7.18 NMNAT2
-
 Homo sapiens
2.7.7.18 NMNAT3
-
 Homo sapiens