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Literature summary extracted from

  • Miralem, T.; Gibbs, P.E.; Revert, F.; Saus, J.; Maines, M.D.
    Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression (2010), J. Biol. Chem., 285, 12551-12558.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.9 TNF-alpha stimulates the autophosphorylation of Goodpasture antigen-binding protein Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.9 expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.9 human biliverdin reductase i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.9 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.9 ATP + [Goodpasture antigen-binding protein] Homo sapiens the Goodpasture antigen-binding protein performs autophosphorylation ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.9 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.9 phosphoprotein Goodpasture antigen-binding protein performs autophosphorylation Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.9 ATP + [Goodpasture antigen-binding protein] the Goodpasture antigen-binding protein performs autophosphorylation Homo sapiens ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.9 Goodpasture antigen-binding protein kinase
-
 Homo sapiens
2.7.11.9 GPBP kinase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.9 7
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.9 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.11.9 Homo sapiens TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase up

General Information

EC Number General Information Comment Organism
2.7.11.9 metabolism downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase Homo sapiens