BRENDA - Enzyme Database show

Nicotinamide phosphoribosyltransferase in human diseases

Zhang, L.Q.; Heruth, D.P.; Ye, S.Q.; J. Bioanal. Biomed. 3, 13-25 (2011)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.4.2.12
-
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.4.2.12
H247A
active site residue, no detectable activity
Homo sapiens
2.4.2.12
H247E
active site residue, low activity
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK-866
i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
55520
-
2 * 55520, theoretic value
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
P43490
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
2.4.2.12
phosphoprotein
autophosphorylation can increase the activity
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
brain
-
Homo sapiens
-
2.4.2.12
heart
-
Homo sapiens
-
2.4.2.12
kidney
-
Homo sapiens
-
2.4.2.12
liver
-
Homo sapiens
-
2.4.2.12
lung
-
Homo sapiens
-
2.4.2.12
lymphocyte
-
Homo sapiens
-
2.4.2.12
pancreas
-
Homo sapiens
-
2.4.2.12
placenta
-
Homo sapiens
-
2.4.2.12
skeletal muscle
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phosphoribosyl 1-diphosphate
-
722560
Homo sapiens
nicotinamide mononucleotide + diphosphate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.4.2.12
homodimer
2 * 55520, theoretic value
Homo sapiens
pI Value
EC Number
Organism
Commentary
pI Value Maximum
pI Value
2.4.2.12
Homo sapiens
theoretic value
-
6.69
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.4.2.12
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.4.2.12
H247A
active site residue, no detectable activity
Homo sapiens
2.4.2.12
H247E
active site residue, low activity
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK-866
i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
55520
-
2 * 55520, theoretic value
Homo sapiens
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
2.4.2.12
phosphoprotein
autophosphorylation can increase the activity
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
brain
-
Homo sapiens
-
2.4.2.12
heart
-
Homo sapiens
-
2.4.2.12
kidney
-
Homo sapiens
-
2.4.2.12
liver
-
Homo sapiens
-
2.4.2.12
lung
-
Homo sapiens
-
2.4.2.12
lymphocyte
-
Homo sapiens
-
2.4.2.12
pancreas
-
Homo sapiens
-
2.4.2.12
placenta
-
Homo sapiens
-
2.4.2.12
skeletal muscle
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phosphoribosyl 1-diphosphate
-
722560
Homo sapiens
nicotinamide mononucleotide + diphosphate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.4.2.12
homodimer
2 * 55520, theoretic value
Homo sapiens
pI Value (protein specific)
EC Number
Organism
Commentary
pI Value Maximum
pI Value
2.4.2.12
Homo sapiens
theoretic value
-
6.69
General Information
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis
Homo sapiens
2.4.2.12
physiological function
growth factor, cytokine and nicotinamide phosphoribosyltransferase
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
implicated in the pathogenesis of a number of human diseases or conditions such as acute lung injury, aging, atherosclerosis, cancer, diabetes, rheumatoid arthritis and sepsis
Homo sapiens
2.4.2.12
physiological function
growth factor, cytokine and nicotinamide phosphoribosyltransferase
Homo sapiens