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Literature summary extracted from

  • Inokoshi, J.; Nakamura, Y.; Hongbin, Z.; Uchida, R.; Nonaka, K.; Masuma, R.; Tomoda, H.
    Spirohexalines, new inhibitors of bacterial undecaprenyl pyrophosphate synthase, produced by Penicillium brasilianum FKI-3368 (2013), J. Antibiot., 66, 37-41.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.31 spirohexaline
-
 Penicillium brasilianum
2.5.1.31 viridicatumtoxin
-
 Penicillium brasilianum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.31 Penicillium brasilianum
-
-
-
2.5.1.31 Penicillium brasilianum FKI-3368
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.5.1.31 undecaprenyl pyrophosphate synthase
-
 Penicillium brasilianum
2.5.1.31 UPP synthase
-
 Penicillium brasilianum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.31 0.004
-
 pH and temperature not specified in the publication Penicillium brasilianum viridicatumtoxin
2.5.1.31 0.009
-
 pH and temperature not specified in the publication Penicillium brasilianum spirohexaline

General Information

EC Number General Information Comment Organism
2.5.1.31 physiological function undecaprenyl diphosphate is a key lipid involved in the biosynthesis of peptidoglycan and other cell wall polysaccharide components, such as lipopolysaccharides, enterobacterial common antigen, capsule polysaccharides and teichoic acids. In the cell wall synthetic pathway, UPP is needed for the synthesis and transport of hydrophilic GlcNAc-MurNAc-pentapeptides across the hydrophobic environment of the cytoplasmic membrane to the externally located sites of polymerization Penicillium brasilianum