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Literature summary extracted from

  • Caldas, H.; Herman, G.E.
    NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets (2003), Hum. Mol. Genet., 12, 2981-91.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.170 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.170 lipid droplet surface of Homo sapiens 5811
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Organism

EC Number Organism UniProt Comment Textmining
1.1.1.170 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.170 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+ enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis Homo sapiens 4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
 ?
1.1.1.170 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+ enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis Homo sapiens 5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.170 C-3 sterol dehydrogenase(C-4 decarboxylase)
-
 Homo sapiens
1.1.1.170 NSDHL
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.170 malfunction mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects Homo sapiens