BRENDA - Enzyme Database

NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets

Caldas, H.; Herman, G.E.; Hum. Mol. Genet. 12, 2981-91 (2003) View publication on PubMed

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.170
endoplasmic reticulum
-
Homo sapiens
5783
-
1.1.1.170
lipid droplet
surface of
Homo sapiens
5811
-
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.1.1.170
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.1.1.170
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
-
-
?
1.1.1.170
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.1.1.170
C-3 sterol dehydrogenase(C-4 decarboxylase)
-
Homo sapiens
1.1.1.170
NSDHL
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.170
endoplasmic reticulum
-
Homo sapiens
5783
-
1.1.1.170
lipid droplet
surface of
Homo sapiens
5811
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.1.1.170
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
-
-
?
1.1.1.170
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.1.1.170
malfunction
mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.170
malfunction
mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects
Homo sapiens