EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.232 | Trypanosoma brucei | - |
gene ALG12 | - |
2.4.1.260 | Trypanosoma brucei | - |
- |
- |
2.4.1.260 | Trypanosoma brucei | - |
gene ALG12 | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.232 | alpha1-6-mannosyltransferase | - |
Trypanosoma brucei |
2.4.1.232 | Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase | - |
Trypanosoma brucei |
2.4.1.232 | TbALG12 | - |
Trypanosoma brucei |
2.4.1.260 | ALG12 | - |
Trypanosoma brucei |
2.4.1.260 | alpha1-6-mannosyltransferase | - |
Trypanosoma brucei |
2.4.1.260 | Dol-P-Man:Man7GlcNAc2-PP-Dol-alpha1-6-mannosyltransferase | - |
Trypanosoma brucei |
2.4.1.260 | TbALG12 | - |
Trypanosoma brucei |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.232 | malfunction | the variant surface glycoprotein sVSG221 synthesized by the ALG12-/- parasites shows different glycosylation patterns to that synthesized by wild-type cells, changes in sVSG221 glycosylation induced by the deletion of the ALG12 gene, overview | Trypanosoma brucei |
2.4.1.232 | physiological function | the TbALG12 gene encodes the alpha1-6-mannosyltransferase that converts Man7GlcNAc2-PP-Dol to Man8GlcNAc2-PP-Dol | Trypanosoma brucei |
2.4.1.260 | malfunction | the variant surface glycoprotein sVSG221 synthesized by the ALG12-/- parasites shows different glycosylation patterns to that synthesized by wild-type cells, changes in sVSG221 glycosylation induced by the deletion of the ALG12 gene, overview | Trypanosoma brucei |
2.4.1.260 | physiological function | oligosaccharyltransferase TbSTT3A is able to transfer Man7GlcNAc2 as well as Man5GlcNAc2 to its preferred acidic glycosylation site at residue Asn263 of variant surface protein. In a mutant lacking enzymic activity, i.e. in the absence of Man9GlcNAc2-PP-Dol, oligosaccharyltransferase TbSTT3B transfers both Man7GlcNAc2 and Man5GlcNAc2 to the remaining site at Asn428 of variant surface protein, albeit with low efficiency | Trypanosoma brucei |
2.4.1.260 | physiological function | the TbALG12 gene encodes the alpha1-6-mannosyltransferase that converts Man7GlcNAc2-PP-Dol to Man8GlcNAc2-PP-Dol | Trypanosoma brucei |