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Literature summary extracted from

  • Walker, L.R.; Simcock, D.C.; Pedley, K.C.; Simpson, H.V.; Brown, S.
    The kinetics and regulation of phosphofructokinase from Teladorsagia circumcincta (2012), Exp. Parasitol., 130, 348-353.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.11 additional information D-glucose 1,6-bisphosphate and phosphoenolpyruvate have no effect on activity Teladorsagia circumcincta

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 ATP allosteric inhibition by high ATP concentrations. The inhibitory effects of high ATP concentration can be reversed by D-fructose 2,6-bisphosphate and AMP Teladorsagia circumcincta
2.7.1.11 citrate mild inhibitory effects, but only at concentrations exceeding 2 mM Teladorsagia circumcincta
2.7.1.11 isocitrate mild inhibitory effects, but only at concentrations exceeding 2 mM Teladorsagia circumcincta
2.7.1.11 malate mild inhibitory effects, but only at concentrations exceeding 2 mM Teladorsagia circumcincta

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Teladorsagia circumcincta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 adult
-
 Teladorsagia circumcincta
-
2.7.1.11 larva
-
 Teladorsagia circumcincta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Teladorsagia circumcincta ADP + D-fructose 1,6-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 hosphofructokinase-1
-
 Teladorsagia circumcincta
2.7.1.11 PFK-1
-
 Teladorsagia circumcincta

Expression

EC Number Organism Comment Expression
2.7.1.11 Teladorsagia circumcincta enzyme activities are higher in the adult stage as compared to L3 larval stages up