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Literature summary extracted from

  • Flores, O.; Wang, Z.; Knudsen, K.E.; Burnstein, K.L.
    Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition (2010), Endocrinology, 151, 896-908.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 cyclin E required for activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.22 expression of GFP- and Myc-tagged CDK2 in 293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 additional information generation of human prostate cancer cells that are resistant to growth inhibition by 1,25-dihydroxyvitamin D3 but retain fully functional vitaminD receptors. These cells do not exhibit 1,25-dihydroxyvitamin D3-mediated cytoplasmic relocalization of CDK2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 1,25-dihydroxyvitamin D3 inhibition of CDK2 activity by 1,25-dihydroxyvitamin D3 is associated with decreased T160 phosphorylation, a residue whose phosphorylation in the nucleus is essential for CDK2 activity. 1,25-dihydroxyvitamin D3 increases the stability of the cyclin-dependent kinase inhibitor p27KIP1. Ectopic expression of cyclin E is sufficient to overcome 1,25-dihydroxyvitamin D3-mediated cytoplasmic mislocalization of CDK2 and all antiproliferative effects of 1,25-dihydroxyvitamin D3, yet endogenous levels of cyclin E or binding to CDK2 are not affected by 1,25-dihydroxyvitamin D3. Targeting CDK2 to the nucleus of 1,25-dihydroxyvitamin D3-sensitive cancer cells blocked G1 accumulation and growth inhibition by 1,25-dihydroxyvitamin D3 Homo sapiens
2.7.11.22 cyclin-dependent kinase inhibitor p27KIP1
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.22 cytoplasm
-
 Homo sapiens 5737
-
2.7.11.22 additional information CDK2 nuclear-cytoplasmic trafficking Homo sapiens
-
-
2.7.11.22 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.22 Mg2+ required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.22 phosphoprotein T160 phosphorylation in the nucleus is essential for CDK2 activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 LNCaP cell
-
 Homo sapiens
-
2.7.11.22 prostate cancer cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 CDK2
-
 Homo sapiens
2.7.11.22 cyclin-dependent kinase 2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.22 3
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.22 physiological function role of CDK2 cytoplasmic relocalization in the antiproliferative effects of 1,25-dihydroxyvitamin D3. Central roles for CDK2 nuclear-cytoplasmic trafficking and cyclin E in the mechanism of 1,25-dihydroxyvitamin D3-mediated growth inhibition in prostate cancer cells Homo sapiens