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Literature summary extracted from

  • Haltli, B.; Tan, Y.; Magarvey, N.A.; Wagenaar, M.; Yin, X.; Greenstein, M.; Hucul, J.A.; Zabriskie, T.M.
    Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins (2005), Chem. Biol., 12, 1163-1168.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.40 expression in Escherichia coli Streptomyces hygroscopicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.40 Fe2+ required for activity Streptomyces hygroscopicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.40 38600
-
 x * 38600, protein with an N-terminal His6 tag, calculated from sequence Streptomyces hygroscopicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 Streptomyces hygroscopicus biosynthesis of the nonproteinogenic amino acid beta-hydroxy-enduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotics), produced by Streptomyces hygroscopicus NRRL 30439 (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 Streptomyces hygroscopicus NRRL 30439 biosynthesis of the nonproteinogenic amino acid beta-hydroxy-enduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotics), produced by Streptomyces hygroscopicus NRRL 30439 (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.40 Streptomyces hygroscopicus
-
-
-
1.14.11.40 Streptomyces hygroscopicus NRRL 30439
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.40
-
 Streptomyces hygroscopicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 biosynthesis of the nonproteinogenic amino acid beta-hydroxy-enduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotics), produced by Streptomyces hygroscopicus NRRL 30439 Streptomyces hygroscopicus (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 MppO specifically hydroxylates L-enduracididine Streptomyces hygroscopicus (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 biosynthesis of the nonproteinogenic amino acid beta-hydroxy-enduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotics), produced by Streptomyces hygroscopicus NRRL 30439 Streptomyces hygroscopicus NRRL 30439 (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?
1.14.11.40 L-enduracididine + 2-oxoglutarate + O2 MppO specifically hydroxylates L-enduracididine Streptomyces hygroscopicus NRRL 30439 (3S)-3-hydroxy-L-enduracididine + succinate + CO2
-
 ?
1.14.11.40 additional information no activity with L-arginine or dideoxy-mannopeptimycin-gamma Streptomyces hygroscopicus ?
-
 ?
1.14.11.40 additional information no activity with L-arginine or dideoxy-mannopeptimycin-gamma Streptomyces hygroscopicus NRRL 30439 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.11.40 ? x * 38600, protein with an N-terminal His6 tag, calculated from sequence Streptomyces hygroscopicus

Synonyms

EC Number Synonyms Comment Organism
1.14.11.40 MppO
-
 Streptomyces hygroscopicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.40 30
-
 assay at Streptomyces hygroscopicus

General Information

EC Number General Information Comment Organism
1.14.11.40 malfunction the role of MppO in beta-hydroxyenduracididine biosynthesis is confirmed through inactivation of mppO, which yields a strain that produces dideoxy-mannopeptimycins. MppO is responsible for introducing the beta-hydroxy group of both the D- and L-beta-hydroxyenduracididine residues Streptomyces hygroscopicus
1.14.11.40 physiological function biosynthesis of the nonproteinogenic amino acid beta-hydroxy-enduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotics), produced by Streptomyces hygroscopicus NRRL 30439 Streptomyces hygroscopicus