EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.147 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
2.7.1.147 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.147 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.147 | JURKAT cell | - |
Homo sapiens | - |
2.7.1.147 | T-cell | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.147 | additional information | - |
T cell activation-induces upregulation in ADPGK activity | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.147 | ADP-dependent glucokinase | - |
Homo sapiens |
2.7.1.147 | ADPGK | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.147 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.147 | 6 | - |
assay at | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.147 | malfunction | down-regulation of ADPGK or GPD2 abundance inhibits oxidative signal generation and induction of NF-kappaB-dependent gene expression, whereas over-expression of ADPGK potentiates them | Homo sapiens |
2.7.1.147 | physiological function | T cell activation-induced mitochondrial ROS production and NF-kappaB-driven gene expression depend on activation of ADPGK. ADPGK activation is accompanied by a rapid glucose uptake, downregulation of mitochondrial oxygen consumption, and deviation of glycolysis toward the glycerol-3-phosphate dehydrogenase shuttle | Homo sapiens |