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Literature summary extracted from

  • Haschemi, A.; Kosma, P.; Gille, L.; Evans, C.R.; Burant, C.F.; Starkl, P.; Knapp, B.; Haas, R.; Schmid, J.A.; Jandl, C.; Amir, S.; Lubec, G.; Park, J.; Esterbauer, H.; Bilban, M.; Brizuela, L.; Pospisilik, J.A.; Otterbein, L.E.; Wagner, O.
    The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism (2012), Cell Metab., 15, 813-826.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.14 recombinantly expressed in Escherichia coli Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.14 Q126K mutant shows substantially reduced sedoheptulose kinase activity Mus musculus
2.7.1.14 T14M/T15K mutant shows substantially reduced sedoheptulose kinase activity Mus musculus
2.7.1.14 W125D mutant shows substantially reduced sedoheptulose kinase activity Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.14 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.14 ATP + sedoheptulose
-
 Mus musculus ADP + sedoheptulose 7-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.14 carbohydrate kinase-like protein
-
 Mus musculus
2.7.1.14 CARKL
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.14 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.14 7.6
-
 assay at Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.14 Mus musculus rapidly downregulated in vitro and in vivo upon lipopolysaccharide down

General Information

EC Number General Information Comment Organism
2.7.1.14 physiological function using a screening strategy novel regulators of macrophage activation are identified. CARKL-dependent metabolic reprogramming is required for proper M1- and M2- like macrophage polarization and uncovers a ratelimiting requirement for appropriate glucose flux in macrophage polarization Mus musculus