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Literature summary extracted from

  • Szentpetery, Z.; Szakacs, G.; Bojjireddy, N.; Tai, A.W.; Balla, T.
    Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIalpha (2011), Biochim. Biophys. Acta, 1811, 476-483.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.67 PI4KIIIalpha is one of the genes found in Chr22q11, region affected by chromosomal instability, no substantiation of the existence of a functionally relevant short form of PI4KIIIalpha, expression of a cDNA encoding isoform 1 yields a protein of about 97 kDa that shows no catalytic activity and fails to rescue hepatitis C virus replication. expression in COS-7 cells and HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.67 additional information PI4KIIIalpha isozyme knockout in K-562 cells by siRNA Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidyl-inositol 4-kinase type IIIalpha
-
 Homo sapiens
2.7.1.67 PI4KIIIalpha
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.67 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.67 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.67 evolution in vertebrates, PtdIns4P is synthesized by four distinct PI4K enzymes that belong to either the type-II or type-III family, each having alpha- and beta-forms. The type-III PI4Ks are relatives of the PI 3-kinase family, while the smaller type-II enzymes form a separate family Homo sapiens