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Literature summary extracted from

  • Wu, G.; Sher, R.; Cox, G.; Vance, D.
    Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse (2010), Biochim. Biophys. Acta, 1801, 446-454.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.32 skeletal muscle choline kinase beta is the major isoform in hindlimb muscle and contributes more to choline kinase activity, while choline kinase alpha is predominant in forelimb muscle and contributes more to choline kinase activity Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
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 Mus musculus ADP + phosphocholine
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 choline kinase alpha isoform Mus musculus
2.7.1.32 choline kinase beta isoform Mus musculus
2.7.1.32 CKalpha isoform Mus musculus
2.7.1.32 CKbeta isoform Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.32 Mus musculus choline kinase activity in forelimb and hindlimb muscle decreases with increasing age from 1 to 8 weeks down

General Information

EC Number General Information Comment Organism
2.7.1.32 malfunction deletion of choline kinase gene Chkb results in neonatal forelimb bone deformity and hindlimb muscular dystrophy. The virtual elimination of all choline kinase activity in hindlimb muscle of Chkb-/- mice is not compensated by isoform CKalpha activity and muscular dystrophy develops. In contrast, in forelimb muscles of these mice, the 50% of total choline kinase activity remaining (due to isoform CKalpha), and the increased activity of CTP:phosphocholine cytidylyltransferase, ensure that the amount of phosphocholine is not reduced so that only minimal signs of muscular dystrophy develop as the mice age Mus musculus