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Literature summary extracted from

  • Vande Voorde, J.; Quintiliani, M.; McGuigan, C.; Liekens, S.; Balzarini, J.
    Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative (2012), Biochem. Pharmacol., 83, 1358-1363.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
-
 Homo sapiens
2.4.2.1 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate competitive inhibition with regard to inosine Mycoplasma hyorhinis
2.4.2.2 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate competitive inhibition with regard to inosine Mycoplasma hyorhinis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.1 0.491
-
 Inosine pH 7.6, 37°C Homo sapiens
2.4.2.1 1.796
-
 Inosine pH 7.6, 37°C Mycoplasma hyorhinis
2.4.2.2 0.31
-
 uridine pH 7.6, 37°C Mycoplasma hyorhinis
2.4.2.2 1.093
-
 thymidine pH 7.6, 37°C Mycoplasma hyorhinis

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Homo sapiens
-
-
-
2.4.2.1 Mycoplasma hyorhinis
-
-
-
2.4.2.2 Mycoplasma hyorhinis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 inosine + phosphate
-
 Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.1 inosine + phosphate
-
 Mycoplasma hyorhinis hypoxanthine + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.2 5-fluorouridine + phosphate
-
 Mycoplasma hyorhinis 5-fluorouracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.2 5-iododeoxyuridine + phosphate
-
 Mycoplasma hyorhinis 5-iodouracil + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.2 thymidine + phosphate
-
 Mycoplasma hyorhinis thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.2 uridine + phosphate preferred substrate Mycoplasma hyorhinis uracil + alpha-D-ribose 1-phosphate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.1 0.27
-
 pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
2.4.2.1 0.372
-
 pH 7.6, 37°C Homo sapiens 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
2.4.2.2 0.113
-
 substrate deoxythymidine, pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
2.4.2.2 0.128
-
 substrate 5-fluorodeoxyuridine, pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
2.4.2.2 0.159
-
 substrate 5-iododeoxyuridine pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate
2.4.2.2 0.188
-
 substrate uridine, pH 7.6, 37°C Mycoplasma hyorhinis 3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate