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Literature summary extracted from

  • Sakuno, E.; Wen, Y.; Hatabayashi, H.; Arai, H.; Aoki, C.; Yabe, K.; Nakajima, H.
    Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis (2005), Appl. Environ. Microbiol., 71, 2999-3006.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.142 expression in Pichia pastoris Aspergillus parasiticus
4.2.1.143 expression in Pichia pastoris Aspergillus parasiticus

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.142 additional information truncation of the N-terminal 41-amino-acid region may not affect the substrate specificity Aspergillus parasiticus
4.2.1.143 additional information truncation of the N-terminal 41-amino-acid region may not affect the substrate specificity Aspergillus parasiticus

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.142 Aspergillus parasiticus Q12062 VBS
-
4.2.1.142 Aspergillus parasiticus NRRL 2999 Q12062 VBS
-
4.2.1.143 Aspergillus parasiticus Q12062 VBS
-
4.2.1.143 Aspergillus parasiticus NRRL 2999 Q12062 VBS
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.142 5'-oxoaverantin i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione Aspergillus parasiticus (2'S,5'S)-averufin + H2O i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione ?
4.2.1.142 5'-oxoaverantin i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione Aspergillus parasiticus NRRL 2999 (2'S,5'S)-averufin + H2O i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione ?
4.2.1.142 additional information in addition, enzyme catalyzes the conversion of versiconal to versicolorin B, reaction of EC 4.2.1.143, versicolorin B synthase Aspergillus parasiticus ?
-
 ?
4.2.1.142 additional information in addition, enzyme catalyzes the conversion of versiconal to versicolorin B, reaction of EC 4.2.1.143, versicolorin B synthase Aspergillus parasiticus NRRL 2999 ?
-
 ?
4.2.1.143 additional information in addition, enzyme catalyzes the conversion of 5'-oxoaverantin to (2'S,5'S)-averufin, reaction of EC 4.2.1.142, 5'-oxoaverantin cyclase Aspergillus parasiticus ?
-
 ?
4.2.1.143 additional information in addition, enzyme catalyzes the conversion of 5'-oxoaverantin to (2'S,5'S)-averufin, reaction of EC 4.2.1.142, 5'-oxoaverantin cyclase Aspergillus parasiticus NRRL 2999 ?
-
 ?
4.2.1.143 versiconal i.e. (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione Aspergillus parasiticus versicolorin B + H2O (3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione ?
4.2.1.143 versiconal i.e. (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione Aspergillus parasiticus NRRL 2999 versicolorin B + H2O (3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.142 VBS
-
 Aspergillus parasiticus
4.2.1.142 versicolorin B synthase
-
 Aspergillus parasiticus
4.2.1.143 VBS
-
 Aspergillus parasiticus
4.2.1.143 versicolorin B synthase
-
 Aspergillus parasiticus

General Information

EC Number General Information Comment Organism
4.2.1.142 physiological function enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour Aspergillus parasiticus
4.2.1.143 physiological function enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour Aspergillus parasiticus