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Literature summary extracted from

  • Kumagai, T.; Koyama, Y.; Oda, K.; Noda, M.; Matoba, Y.; Sugiyama, M.
    Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae (2010), Antimicrob. Agents Chemother., 54, 1132-1139.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.25 expression in Escherichia coli Streptomyces lavendulae
5.1.1.19
-
 Streptomyces lavendulae subsp. lavendulae
6.3.3.5
-
 Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.99.3 O-acetyl-L-serine + hydroxyurea Streptomyces lavendulae the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species O-ureido-L-serine + acetate
-
 ?
2.6.99.3 O-acetyl-L-serine + hydroxyurea Streptomyces lavendulae ATCC 11924 the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species O-ureido-L-serine + acetate
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O Streptomyces lavendulae the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species L-ornithine + hydroxyurea
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O Streptomyces lavendulae ATCC 11924 the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species L-ornithine + hydroxyurea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.99.3 Streptomyces lavendulae D2Z027
-
-
2.6.99.3 Streptomyces lavendulae ATCC 11924 D2Z027
-
-
3.5.3.25 Streptomyces lavendulae D2Z025
-
-
3.5.3.25 Streptomyces lavendulae ATCC 11924 D2Z025
-
-
5.1.1.19 Streptomyces lavendulae subsp. lavendulae D2Z026
-
-
6.3.3.5 Streptomyces lavendulae D2Z030
-
-
6.3.3.5 Streptomyces lavendulae ATCC 11924 D2Z030
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.25
-
 Streptomyces lavendulae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.99.3 O-acetyl-L-serine + hydroxyurea the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae O-ureido-L-serine + acetate
-
 ?
2.6.99.3 O-acetyl-L-serine + hydroxyurea O-ureido-L-serine i.e. (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate Streptomyces lavendulae O-ureido-L-serine + acetate
-
 ?
2.6.99.3 O-acetyl-L-serine + hydroxyurea the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae ATCC 11924 O-ureido-L-serine + acetate
-
 ?
2.6.99.3 O-acetyl-L-serine + hydroxyurea O-ureido-L-serine i.e. (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate Streptomyces lavendulae ATCC 11924 O-ureido-L-serine + acetate
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae L-ornithine + hydroxyurea
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O L-arginine is not a substrate Streptomyces lavendulae L-ornithine + hydroxyurea
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae ATCC 11924 L-ornithine + hydroxyurea
-
 ?
3.5.3.25 Nomega-hydroxy-L-arginine + H2O L-arginine is not a substrate Streptomyces lavendulae ATCC 11924 L-ornithine + hydroxyurea
-
 ?
5.1.1.19 O-ureido-L-serine O-ureido-L-serine i.e. (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate Streptomyces lavendulae subsp. lavendulae O-ureido-D-serine O-ureido-D-serine i.e. (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate ?
6.3.3.5 O-ureido-D-serine + ATP + H2O O-ureido-D-serine i.e. (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate Streptomyces lavendulae D-cycloserine + CO2 + ammonia + ADP + phosphate
-
 ?
6.3.3.5 O-ureido-D-serine + ATP + H2O O-ureido-D-serine i.e. (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate Streptomyces lavendulae ATCC 11924 D-cycloserine + CO2 + ammonia + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.99.3 DcsD
-
 Streptomyces lavendulae
3.5.3.25 DcsB
-
 Streptomyces lavendulae
5.1.1.19 DcsC
-
 Streptomyces lavendulae subsp. lavendulae
6.3.3.5 DcsG
-
 Streptomyces lavendulae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.3.25 37
-
 assay at Streptomyces lavendulae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.3.25 8
-
 assay at Streptomyces lavendulae

General Information

EC Number General Information Comment Organism
3.5.3.25 physiological function the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae