EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.226 | malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O | Pectobacterium carotovorum | the enzyme catalyzes committed step in the biosynthesis of (5R)-carbapenem-3-carboxylic acid, the simplest of the medicinally important carbapenem antibiotics | CoA + (2S,5S)-5-carboxymethylproline + CO2 | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.226 | Pectobacterium carotovorum | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.226 | malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O | the enzyme catalyzes committed step in the biosynthesis of (5R)-carbapenem-3-carboxylic acid, the simplest of the medicinally important carbapenem antibiotics | Pectobacterium carotovorum | CoA + (2S,5S)-5-carboxymethylproline + CO2 | - |
? | |
2.3.1.226 | malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O | CarB is a member of the crotonase superfamily of enzymes. In addition to decarboxylation and thioester hydrolysis steps, it catalyzes C-C bond formation leading to a substituted heterocycle. Mechanistic studies show that C-C bond formation by CarB most probably occurs by reaction of P5C with an oxy-anion stabilized enolate, and thioester hydrolysis most probably proceeds by direct attack of an activated water molecule | Pectobacterium carotovorum | CoA + (2S,5S)-5-carboxymethylproline + CO2 | - |
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EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.226 | CarB | - |
Pectobacterium carotovorum |