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Literature summary extracted from

  • Scheller, J.; Chalaris, A.; Garbers, C.; Rose-John, S.
    ADAM17: A molecular switch to control inflammation and tissue regeneration (2011), Trends Immunol., 32, 380-387.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 phorbol 12-myristate 13-acetate potent activator of ADAM17 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.86 T735A the mutant has a basal TGF-alpha shedding activity lower than that of wild type cells and shedding is not induced by p38 MAPK Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 tissue inhibitor of metalloproteinase-3
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.86 AREG + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 CD26L + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 FLT-3L + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 GPIba + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 HB-EGF + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 ICAM-1 + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 interleukin-6 receptor + H2O Mus musculus
-
 soluble interleukin-6 receptor + ?
-
 ?
3.4.24.86 L-selectin + H2O Mus musculus ADAM17 is the main sheddase of the adhesion protein L-selectin ?
-
 ?
3.4.24.86 Notch1 + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 p55 TNF-alpha RI + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 p75 TNF-alpha RII + H2O Mus musculus
-
 ?
-
 ?
3.4.24.86 proTGF-alpha + H2O Mus musculus
-
 soluble TGF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O Mus musculus
-
 soluble TNF-alpha + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 ACE2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 ALCAM + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 AREG + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD163 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD26L + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD30 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD40 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD44 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD89 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CD91 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 collagen type XVII + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CSF-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 CSF1R + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 DLL1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 DSG2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 EpCAM + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 EPCR + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 epigen + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 ErbB4 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 EREG + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 FLT-3L + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 fractalkine + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 GPIba + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 HB-EGF + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 heregulin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 ICAM-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 IGF-2 receptor + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 interleukin-1 receptor 2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 interleukin-6 receptor + H2O
-
 Mus musculus soluble interleukin-6 receptor + ?
-
 ?
3.4.24.86 Jagged protein + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 JAM-A + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 KL-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 KL-2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 L-selectin + H2O ADAM17 is the main sheddase of the adhesion protein L-selectin Mus musculus ?
-
 ?
3.4.24.86 L1-CAM + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 LAG-3 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 LOX-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 lymphotoxin-alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 LYPD3 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 MICA + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 MICB + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 MUC-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 NCAM + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 nectin-4 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 Notch1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 NPR + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 p55 TNF-alpha RI + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 p75 TNF-alpha RII + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 p75NTR + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 PMEL17 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 Pref1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 proTGF-alpha + H2O
-
 Mus musculus soluble TGF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha + ?
-
 ?
3.4.24.86 PrPc + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 PTP-LAR + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 Ptprz + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SDC1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SDC4 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SEMA4D + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SORCS1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 sorCS3 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SORL1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 SORT1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 TMEFF2 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 TRANCE/RANKL + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 TrkA + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 vasorin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 VCAM-1 + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 VEGFR2 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM17
-
 Mus musculus
3.4.24.86 TACE
-
 Mus musculus
3.4.24.86 tumor necrosis factor-alpha converting enzyme
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.24.86 Mus musculus ADAM17 is upregulated in most tumor cells up

General Information

EC Number General Information Comment Organism
3.4.24.86 malfunction ADAM17-deficient mice have defects in the mammary epithelium, vascular system, lung, eye, hair, heart and skin and as a result die between embryonic day 17.5 and the first few days after birth Mus musculus
3.4.24.86 physiological function ADAM17 plays an in vivo role in controlling inflammation and tissue regeneration. ADAM17 modulates inflammation by activation of TNFR- and IL-6R-mediated signal transduction. ADAM17 activity regulates both homeostatic and activation-induced changes in cell surface L-selectin density and, thus, might direct the migration patterns of activated lymphocytes and neutrophils in vivo. Apoptosis leads to activation of ADAM17. During ADAM17 maturation, the prodomain is removed by furin cleavage. ADAM17 protects hepatocytes from apoptosis Mus musculus