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Literature summary extracted from

  • Bromberg-White, J.; Lee, C.S.; Duesbery, N.
    Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin (2010), Toxins, 2, 1038-1053.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.83 E687C inactive Bacillus anthracis
3.4.24.83 H686A inactive Bacillus anthracis
3.4.24.83 H690A inactive Bacillus anthracis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.83 Zn2+ a zinc-dependent metalloprotease Bacillus anthracis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.83 90000
-
 x * 90000, SDS-PAGE Bacillus anthracis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase kinase 1 + H2O Bacillus anthracis
-
 ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 2 + H2O Bacillus anthracis
-
 ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 3 + H2O Bacillus anthracis
-
 ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 4 + H2O Bacillus anthracis
-
 ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 6 + H2O Bacillus anthracis
-
 ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 7 + H2O Bacillus anthracis
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase kinase 1 + H2O
-
 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 2 + H2O
-
 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 3 + H2O
-
 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 4 + H2O
-
 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 6 + H2O
-
 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase kinase 7 + H2O
-
 Bacillus anthracis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.83 ? x * 90000, SDS-PAGE Bacillus anthracis

Synonyms

EC Number Synonyms Comment Organism
3.4.24.83 anthrax lethal factor
-
 Bacillus anthracis
3.4.24.83 lethal toxin
-
 Bacillus anthracis
3.4.24.83 LeTx
-
 Bacillus anthracis

General Information

EC Number General Information Comment Organism
3.4.24.83 physiological function lethal toxin (LeTx) containing lethal factor is the major virulence factor contributing to anthrax. LeTx-mediated MAPKK inhibition alters endothelial cell function Bacillus anthracis