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Literature summary extracted from

  • Rakauskaite, R.; Dinman, J.D.
    Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes (2011), RNA, 17, 855-864.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.12 expressed in Escherichia coli DH5alpha cells Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.12 additional information three bases in the catalytic core of the peptidyltransferase center - A2819-20 (A2450 and A2451) and U2875 (U2506) - are hyperprotected from 1M7 reagent but not dimethylsulfate modification in U2861A ribosomes Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 valnemulin
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.12 ribosome
-
 Saccharomyces cerevisiae 5840
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 AcPhe-tRNA + puromycin
-
 Saccharomyces cerevisiae tRNA + AcPhe-puromycin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.12 PTC peptidyltransferase center Saccharomyces cerevisiae