EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.228 | 5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | - |
Escherichia coli | |
2.1.1.228 | 5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | 6-Chloropurine | - |
Escherichia coli | |
2.1.1.228 | 6-Chloropurine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | adenosine | - |
Escherichia coli | |
2.1.1.228 | adenosine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | AdoButyn | an S-adenosyl-L-methionine analogue | Escherichia coli | |
2.1.1.228 | AdoButyn | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
2.1.1.228 | AdoPropen | an S-adenosyl-L-methionine analogue | Escherichia coli | |
2.1.1.228 | AdoPropen | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
2.1.1.228 | Inosine | - |
Escherichia coli | |
2.1.1.228 | Inosine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | methionine | - |
Escherichia coli | |
2.1.1.228 | methionine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | methylthioadenosine | - |
Escherichia coli | |
2.1.1.228 | methylthioadenosine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | additional information | fragments of S-adenosyl-L-methionine, adenosine and methionine, are selectively inhibitory of TrmD, while they are poor inhibitors for Trm5 from Methanocaldococcus jannaschii | Escherichia coli | |
2.1.1.228 | additional information | fragments of S-adenosyl-L-methionine, adenosine and methionine, are poor inhibitors of Trm5, while they are selectve inhibitors for TrmD from Escherichia coli | Methanocaldococcus jannaschii | |
2.1.1.228 | S-adenosyl-L-homocysteine | an S-adenosyl-L-methionine analogue | Escherichia coli | |
2.1.1.228 | S-adenosyl-L-homocysteine | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii | |
2.1.1.228 | S-methyl-L-cysteine | - |
Escherichia coli | |
2.1.1.228 | S-methyl-L-cysteine | - |
Methanocaldococcus jannaschii | |
2.1.1.228 | sinefungin | an S-adenosyl-L-methionine analogue | Escherichia coli | |
2.1.1.228 | sinefungin | an S-adenosyl-L-methionine analogue | Methanocaldococcus jannaschii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.228 | additional information | - |
additional information | S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview | Escherichia coli | |
2.1.1.228 | additional information | - |
additional information | S-adenosyl-L-methionine and adenosine binding kinetics and kinetic analysis of enzyme reaction, overview | Methanocaldococcus jannaschii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.228 | S-adenosyl-L-methionine + guanine37 in tRNA | Escherichia coli | - |
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? | |
2.1.1.228 | S-adenosyl-L-methionine + guanine37 in tRNA | Methanocaldococcus jannaschii | - |
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.228 | Escherichia coli | - |
- |
- |
2.1.1.228 | Methanocaldococcus jannaschii | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.228 | S-adenosyl-L-methionine + guanine37 in tRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? | |
2.1.1.228 | S-adenosyl-L-methionine + guanine37 in tRNA | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.228 | TRM5 | - |
Methanocaldococcus jannaschii |
2.1.1.228 | TrmD | - |
Escherichia coli |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.228 | 37 | - |
assay at | Escherichia coli |
2.1.1.228 | 55 | - |
assay at | Methanocaldococcus jannaschii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.228 | S-adenosyl-L-methionine | Trm5 binding structure, detailed overview | Methanocaldococcus jannaschii | |
2.1.1.228 | S-adenosyl-L-methionine | TrmD binding structure, detailed overview | Escherichia coli |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.228 | additional information | - |
additional information | inhibition kinetics of S-adenosyl-L-methionine analogues, overview | Escherichia coli | |
2.1.1.228 | additional information | - |
additional information | inhibition kinetics of S-adenosyl-L-methionine analogues, overview | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.00033 | - |
sinefungin | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.00049 | - |
S-adenosyl-L-homocysteine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.00062 | - |
sinefungin | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.0012 | - |
methylthioadenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.00143 | - |
AdoPropen | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.0031 | - |
AdoButyn | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.0042 | - |
S-adenosyl-L-homocysteine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.0079 | - |
AdoButyn | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.01 | - |
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.014 | - |
5'-[(2-aminoethyl)thio]-5'-deoxy-adenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.0259 | - |
AdoPropen | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.03 | - |
methylthioadenosine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.0347 | - |
adenosine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.0642 | - |
adenosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.405 | - |
6-Chloropurine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 0.461 | - |
6-Chloropurine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 0.488 | - |
Inosine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 6.7 | - |
methionine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 13.4 | - |
Inosine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii | |
2.1.1.228 | 18.2 | - |
methionine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 33 | - |
S-methyl-L-cysteine | pH not specified in the publication, 37°C | Escherichia coli | |
2.1.1.228 | 44 | - |
S-methyl-L-cysteine | pH not specified in the publication, 55°C | Methanocaldococcus jannaschii |