Literature summary extracted from
Ribeiro, A.L.; Degiacomi, G.; Ewann, F.; Buroni, S.; Incandela, M.L.; Chiarelli, L.R.; Mori, G.; Kim, J.; Contreras-Dominguez, M.; Park, Y.S.; Han, S.J.; Brodin, P.; Valentini, G.; Rizzi, M.; Riccardi, G.; Pasca, M.R.
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis (2011), PLoS ONE, 6, e26675.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.1.98.3 |
expression in Escherichia coli |
Mycolicibacterium smegmatis |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.1.98.3 |
additional information |
isolation of mutant strains resistant to dinitrobenzamides. All mutants show cross-resistance to benzothiazinones and dinitrobenzamides, and all the mutant strains with a higher level of resistance to dinitrobenzamides have a substitution C394G of MSMEG_6382 gene encoding decaprenylphospho-?-D-ribofuranose 2-oxidase |
Mycolicibacterium smegmatis |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.1.98.3 |
additional information |
benzothiazinone and dinitrobenzamide inhibitors target decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1. Several mutants showing high levels of dinitrobenzamide resistance, exhibit a mutation in residue Cys394 of DprE1 |
Mycolicibacterium smegmatis |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.1.98.3 |
Mycolicibacterium smegmatis |
A0R607 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.1.98.3 |
DprE2 |
- |
Mycolicibacterium smegmatis |
1.1.98.3 |
MSMEG_6382 |
- |
Mycolicibacterium smegmatis |