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Literature summary extracted from

  • Khare, S.; Linster, C.L.; Clarke, S.G.
    The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans (2011), PLoS ONE, 6, e20850.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans N2
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans PL51
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Caenorhabditis elegans
-
-
-
2.1.1.77 Caenorhabditis elegans N2
-
-
-
2.1.1.77 Caenorhabditis elegans PL51
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY
-
 Caenorhabditis elegans N2 S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + KASA-L-isoaspartyl-LAKY
-
 Caenorhabditis elegans PL51 S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Caenorhabditis elegans N2 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Caenorhabditis elegans PL51 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 PCM-1
-
 Caenorhabditis elegans
2.1.1.77 protein L-isoaspartyl methyltransferase
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.1.1.77 physiological function enzyme overexpressor adult animals display increased resistance to severe thermal stress (37°C). The enzyme plays a signaling role in lifespan extension that involves the insulin/insulin-like growth factor-1 signaling pathway, but is independent of its function in overall protein repair. Enzyme overexpression extends lifespan in a DAF-16-dependent manner under mild thermal stress (25°C) Caenorhabditis elegans