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Literature summary extracted from

  • Carland, F.; Fujioka, S.; Nelson, T.
    The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products (2010), Plant Physiol., 153, 741-756.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.143 S-adenosyl-L-methionine + 24-methylenelophenol Arabidopsis thaliana
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 S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.142 Arabidopsis thaliana
-
-
-
2.1.1.143 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.143 S-adenosyl-L-methionine + 24-methylenelophenol
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.142 SMT-2
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 Arabidopsis thaliana
2.1.1.142 SMT-3
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 Arabidopsis thaliana
2.1.1.143 C-24 SMT
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 Arabidopsis thaliana
2.1.1.143 SMT2
-
 Arabidopsis thaliana
2.1.1.143 sterol methyltransferase
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.1.1.142 malfunction Deficiency of SMT2 in the cvp1 mutant results in moderate developmental defects, including aberrant cotyledon vein patterning, serrated floral organs, and reduced stature, but plants are viable, suggesting that SMT3 activity can substitute for the loss of SMT2. The overexpression of SMT3 complements the cotyledon venation pattern defects of cvp1 (SMT2) mutants Arabidopsis thaliana
2.1.1.142 malfunction smt3 single mutants appear wild type, cvp1 smt3 double mutants show enhanced defects relative to cvp1 mutants, such as discontinuous cotyledon vein pattern, and produce novel phenotypes, including defective root growth, loss of apical dominance, sterility, and homeotic floral transformations. Antisense smt3 plants did not display a phenotype, suggesting that SMT3 and SMT2 are functionally redundant Arabidopsis thaliana
2.1.1.143 evolution SMT2 and SMT3 genes are highly homologous and encode highly similar sterol 24-carbon methyltransferases Arabidopsis thaliana
2.1.1.143 malfunction deficiency of SMT2 in the cvp1 mutant results in moderate developmental defects, including aberrant cotyledon vein patterning, serrated floral organs, and reduced stature, but plants are viable, suggesting that SMT3 activity can substitute for the loss of SMT2, overview. Mutation in both SMT2 and SMT3 causes extreme alteration in sterol composition, sterol profiles of smt mutants, overview. Mutants deficient in both SMT1 and SMT2 are embryo lethal. Phenotypes, detailed overview Arabidopsis thaliana
2.1.1.143 metabolism SMT2 and SMT3 are involved in the phytosterol biosynthetic pathway, overview Arabidopsis thaliana
2.1.1.143 physiological function gene SMT2 encodes a C-24 SMT, that catalyzes the reaction that distinguishes the synthesis of structural sterols from signaling brassinosteroid derivatives and is highly regulated. Distinct developmental roles of SMT2 and SMT3, SMT3, which also encodes a C-24 SMT, overview Arabidopsis thaliana