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Literature summary extracted from
- Arginine metabolising enzymes as therapeutic tools for Alzheimers disease: peptidyl arginine deiminase catalyses fibrillogenesis of beta-amyloid peptides (2010), Mol. Neurobiol., 41, 149-158.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.3.15 | 1.35 | - |
Nalpha-benzoyl-L-arginine ethyl ester | pH 7.5, 68°C | Bos taurus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.3.15 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.3.15 | PAD is purified in 12.5% yield and 137fold from bovine brain by chromatography on diethylaminoethyl (DEAE)-sephacel | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.3.15 | brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.3.15 | 59 | - |
pH 7.5, 68°C | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.3.15 | additional information | PAD II not only binds with the beta-amyloid peptides Abeta1-40, Abeta22-35, Abeta17-28,Abeta25-35 and Abeta32-35 but assists in the proteolytic degradation of these peptides with the concomitant formation of insoluble fibrils | Bos taurus | ? | - |
? | |
| 3.5.3.15 | Nalpha-benzoyl-L-arginine ethyl ester + H2O | - |
Bos taurus | Nalpha-benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.3.15 | PAD II | - |
Bos taurus |
| 3.5.3.15 | peptidylarginine deiminase | - |
Bos taurus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.3.15 | 68 | - |
- |
Bos taurus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.3.15 | 68 | - |
enzyme loses 50% of its activity within 38 min | Bos taurus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.3.15 | 7.5 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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