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Literature summary extracted from

  • Miao, J.; Fan, Q.; Cui, L.; Li, X.; Wang, H.; Ning, G.; Reese, J.C.; Cui, L.
    The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum (2010), Mol. Microbiol., 78, 883-902.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.48 additional information recombinant protein expressed in prokaryotes and insect cells does not show activity, recombinant protein purified from the parasites exhibits a predilection to acetylate histone H4 in vitro at K5, K8, K12 and K16 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 cytoplasm and nucleus Plasmodium falciparum 5737
-
2.3.1.48 nucleus and cytoplasm Plasmodium falciparum 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Plasmodium falciparum Q8III2 gene PF11_0192, putative
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
 Plasmodium falciparum CoA + acetylhistone H4 acetylates histone H4 in vitro at K5, K8, K12 and K16 ?
2.3.1.48 additional information protein participates in var gene activation Plasmodium falciparum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 PF11_0192
-
 Plasmodium falciparum

Expression

EC Number Organism Comment Expression
2.3.1.48 Plasmodium falciparum gene PF11_0192 is expressed in erythrocytic stages as a long and a short version additional information

General Information

EC Number General Information Comment Organism
2.3.1.48 physiological function enzyme is essential for asexual intraerythrocytic growth. Overexpression of the long, active or a truncated, non-active version of the protein by stable integration of the expression cassette in the parasite genome results in changes of H4 acetylation and cell cycle progression. Overexpressing parasites shows changes in sensitivity to DNA-damaging agents Plasmodium falciparum