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Literature summary extracted from

  • Draper, J.M.; Xia, Z.; Smith, R.A.; Zhuang, Y.; Wang, W.; Smith, C.D.
    Discovery and evaluation of inhibitors of human ceramidase (2011), Mol. Cancer Ther., 10, 2052-2061.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.23 Ceranib-1 i.e. 3-(3-(4-methoxyphenyl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one Homo sapiens
3.5.1.23 Ceranib-2 i.e. 3-[3-(4-methoxyphenyl)acryloyl]-4-phenyl-1H-quinolin-2-one Homo sapiens
3.5.1.23 D-NMAPPD
-
 Homo sapiens
3.5.1.23 additional information DMAPP has no affect on ceramidase activity up to at least 0.3 mM. N-oleoylethanolamine has no affect on ceramidase activity Homo sapiens
3.5.1.23 N-oleoylethanolamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?
3.5.1.23 N-((2S,3R)-1,3-dihydroxy-5-((2-oxo-2H-chromen-7-yl)oxy)pentan-2-yl)palmitamide + H2O
-
 Homo sapiens palmitate + 2-amino-2,4-dideoxy-5-O-(2-oxo-2H-chromen-7-yl)-D-erythro-pentitol
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.23 0.028
-
 at 37°C, pH not specified in the publication Homo sapiens Ceranib-2
3.5.1.23 0.055
-
 at 37°C, pH not specified in the publication Homo sapiens Ceranib-1